> ## Documentation Index
> Fetch the complete documentation index at: https://docs.revilico.bio/llms.txt
> Use this file to discover all available pages before exploring further.

# Revilico engine benchmarks against experimental data

> How Revilico's engines perform on public benchmark sets, measured against experimental data

## What this tab covers

This tab reports how Revilico's engines perform on public benchmark data sets, compared against experimental measurements. Each benchmark page states:

* which data sets were used;
* which settings were run;
* how the numbers were calculated;
* where the results have known limits.

<Info>
  Every number labelled as a Revilico engine result comes from our own runs with the engine's default settings. Nothing was tuned per target. Reference results from other methods are labelled as published data from their authors.
</Info>

## Available benchmarks

<CardGroup cols={2}>
  <Card title="RevFEP (free energy)" icon="chart-scatter" href="/benchmarks/revfep">
    Relative binding free energies on the public JACS and Merck protein–ligand sets: 17 targets and 389 ligands, compared with experiment and with Schrödinger's published FEP+ results.
  </Card>
</CardGroup>

## RevFEP at a glance

<Frame caption="Averages of the per-target statistics on the JACS and Merck sets. RevFEP numbers are our runs; FEP+ numbers are Schrödinger's published results (release 21-4). See the RevFEP benchmark page for per-target results, an interactive explorer and the methods.">
  <img src="https://mintcdn.com/revilicoinc/2edXI-EuouFEBZx6/images/benchmarks/fep-summary-by-set.png?fit=max&auto=format&n=2edXI-EuouFEBZx6&q=85&s=2227252c75e8a18ae039abadc10611b2" alt="Mean per-target RMSE and Spearman correlation for RevFEP and FEP+" width="1665" height="922" data-path="images/benchmarks/fep-summary-by-set.png" />
</Frame>

| Set | Targets | RevFEP RMSE | FEP+ RMSE | RevFEP ρ | FEP+ ρ |
| - | - | - | - | - | - |
| Overall | 17 | 1.28 | 0.79 | 0.48 | 0.68 |
| JACS | 6 | 1.00 | 0.68 | 0.68 | 0.77 |
| Merck | 11 | 1.43 | 0.85 | 0.38 | 0.64 |

RMSE is in kcal/mol. ρ is the Spearman rank correlation.


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